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By far the most common malignant neoplasm is adenocarcinoma. Bile duct cancer is more common in men: the average age at diagnosis is 60 yr. Tumors of the upper portion of the ducts (50% of all lesions) are intimately related to the liver; those of the middle portion, to the portal vein and hepalic artery; [...]

Papilloma and adenoma are the most common benign neoplasms of the bile ducts, although fibroadenoma, adenomyoma. leiomyoma, granular cell myoblastoma, neurinoma, and hamartoma also occur. Intermittent jaundice and right upper quadrant pain arc the most common symptoms. The treatment of choice is local excision.