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Many drugs adversely affect sexuality (see TABLES 68—1 and 68-2). Some interfere with the autonomic nervous system, which is involved in the sexual response. Others affect mood and alertness or change the production or action of sex hormones. Assessing the effects of drugs on sexuality is more difficult in women than in men, since potency problems in men are more obvious. However, drugs that affect men may also affect women, and further studies in women are warranted.
A patient who suspects that medications are the cause of sexual problems may be tempted to discontinue the drugs or decrease the doses without informing the physician. The possibility of adverse drug effects on sexual function should be discussed openly with patients, who should be encouraged to report any side effects.
Although the effects of specific drugs on sexuality are outlined in TABLES 68-1 and 68-2, some drugs deserve special mention. Antipsychotics, such as thioridazine and other phenothiazines, may inhibit erection or ejaculation, even though the capacity for erection remains. Tranquilizers can depress the sexual responses of women and men, and some antidepressants can inhibit sexual desire.

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